Friday, June 29, 2007

So you're an HIV virion, cruising through some unlucky victim's blood. You dodge some antibodies and breathe a sigh of relief when you cross the cell membrane into a host cell. The next dangerous step is reverse transcribing your RNA into DNA. What with doctors pumping pesky reverse-transcriptase inhibitors into your victim, that can get tricky. But you do it and breathe another sigh of relief. Next you cross into the nucleus and integrate into the host DNA. Once that's done, you're home free, right? Inside your host's DNA, where could you possibly be safer?

Not so fast:

In tests on cultured human tissue, the mutated enzyme, Tre recombinase, snipped HIV DNA out of chromosomes.

This is a really cool approach, and, of course, I hope it pans out.

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